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Korean Journal of Epidemiology 1989;11(2): 215-231.
한 사업장에서의 B형 간염백신 접종후 생성된 항체 발현에 관한 연구
한복순, 김일순, 서일
A study of the seroconversion rates of anti-HBs and the duration of anti-HBs persistence after hepatitis B vaccination
Bok Soon Han, Il Soon Kim, Il Suh
Abstract
When the patients were contracted with acute type B hepatitis, most of them recover completely. But approximately 15-20% of them may have chronic hepatitis, liver cirrhosis or hepatoma. For the prevention of serious type B hepatitis, many different products of vaccine were developed. And there were many researches on the effectiveness, security, and immunity of these products. The purpose of this study is to assess the seroconversion rates of Anti HBs with PHA method and the duration of Anti HBs persistence after hepatitis B vaccination. The factors relevant to the rates and duration were analyzed using x2 test and survival analysis based on the data from self-written questionares, blood test and chart Reviews from Oct 1988 to May 1989. The results were as follows; 1. The seroconversion rates of Anti HBs was 67.2%. 2. The statistically significant variables influencing seroconversion rates of Anti HBs after HBV vaccination were sex, age, type of vaccines, blood types, smoking. 3. The seroconversion rates for male and female were 62.1%, and 75.5%, respectively. These rates were statistically significant(p<0.05). For male, the age specific rates for 19-29, 30-39, 40-49, 50 over were 73.6%, 57.3%, 74.6%, 52.0%, respectively. These rates were also statistically significant(p<0.05). 4. Of the 661 cases of completely HBV vaccinated persons, 444 cases(67.2%) were responders with vaccination. Their 5 year survival rate of Ant HBs was 57.3%. 5. The statistically significant variables influencing survival time of Anti HBs were Q index, and past history of liver diseases. The lower the Q index, the more mean survival time of Anti HBs. The mean survival time of Anti HBs for the persons with no history of liver disease was longer than that of the persons with history of liver disease. 6. The mean survival time of Anti HBs of Q index group for the average weight, overweight and obesity were 55.82 months,51.37 months and 35.57 months, respectively. 7. The mean survival time of Anti HBs for the persons with no history of liver disease, the persons with history of liver disease were 57.31 months and 40.01 months, respectively.


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