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Korean Journal of Epidemiology 1991;13(1): 63-72.
Controlled trial of transdermal nicotine patch in tobacco withdrawal.
Heechul Oh, Ilsoon Kim, Seonha Jee, Taeyong Shon, Cheongmo Nam
To determine the effects of transdermal nicotine patch on the withdrawal of smoking, a randomized, double-blind, placebo-controlled trial with 101 male volunteers was conducted. A total of 71 persons with nicotine patch and 30 with placebo were observed for six weeks. Anti-Smoking education with video, slides, and lectures preceded the trial. Abstinence from smoking was confirmed by urine cotinine level (<300ng/ml) at the end of sixth week of abstinence trial. Sixty-two percents of the nicotine group and 33 percents of placebo group succeeded in withdrawal of smoking respectively after six weeks. Craving indices for tobacco were moderate in both groups, but diminished over the course of treatment. Complication rates of attaching patches amount to 46.5% (33/71) in nicotine group, most frequent ones being itching sensation(23.9%), erythema(12.7%), and difficulty in concentration(9.9%) during the first week. Those of placebo group were 36.7% (11/30), difficulty in concentration(20.0%), itching sensation (16.7%), and erythema(6.7%) respectively. The result of this study showed a evidence that transdermal nicotine patch is effective in smoking withdrawal among persons with desire to abstain from smoking at least for a period of six weeks.
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