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- Data Profile Introduction to the forensic research via omics markers in environmental health vulnerable areas (FROM) study
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Jung-Yeon Kwon1
, Woo Jin Kim2
, Yong Min Cho3
, Byoung-gwon Kim1,4
, Seungho Lee1,4
, Jee Hyun Rho1
, Sang-Yong Eom5
, Dahee Han3
, Kyung-Hwa Choi6
, Jang-Hee Lee7
, Jeeyoung Kim2
, Sungho Won8
, Hee-Gyoo Kang9
, Sora Mun9
, Hyun Ju Yoo10
, Jung-Woong Kim11
, Kwan Lee12
, Won-Ju Park13
, Seongchul Hong14
, Young-Seoub Hong1,4
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Epidemiol Health 2024;46e2024062-0
DOI: https://doi.org/10.4178/epih.e2024062
Published online: July 12, 2024
2Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, Korea
3Department of Nano, Chemical & Biological Engineering, Seokyeong University, Seoul, Korea
4Environmental Health Center for Busan, Dong-A University, Busan, Korea
5Department of Preventive Medicine, Chungbuk National University College of Medicine, Cheongju, Korea
6Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Korea
7SD Medical Research Institute, Yongin, Korea
8Department of Public Health Sciences, Seoul National University, Seoul, Korea
9Department of Biomedical Laboratory Science, Eulji University College of Health Sciences, Seongnam, Korea
10Department of Convergence Medicine, Department of Digital Medicine, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
11Department of Life Sciences, Chung-Ang University, Seoul, Korea
12Department of Preventive Medicine, Dongguk University College of Medicine, Gyeongju, Korea
13Department of Occupational and Environmental Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea
14Department of Preventive Medicine, Jeju National University College of Medicine, Jeju, Korea
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Corresponding author:
Young-Seoub Hong,
Email: yshong@dau.ac.kr
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Abstract
This research group (forensic research via omics markers in environmental health vulnerable areas: FROM) aimed to develop biomarkers for exposure to environmental hazards and diseases, assess environmental diseases, and apply and verify these biomarkers in environmentally vulnerable areas. Environmentally vulnerable areas—including refineries, abandoned metal mines, coal-fired power plants, waste incinerators, cement factories, and areas with high exposure to particulate matter—along with control areas, were selected for epidemiological investigations. A total of 1,157 adults, who had resided in these areas for over 10 years, were recruited between June 2021 and September 2023. Personal characteristics of the study participants were gathered through a survey. Biological samples, specifically blood and urine, were collected during the field investigations, separated under refrigerated conditions, and then transported to the laboratory for biomarker analysis. Analyses of heavy metals, environmental hazards, and adducts were conducted on these blood and urine samples. Additionally, omics analyses of epigenomes, proteomes, and metabolomes were performed using the blood samples. The biomarkers identified in this study will be utilized to assess the risk of environmental disease occurrence and to evaluate the impact on the health of residents in environmentally vulnerable areas, following the validation of diagnostic accuracy for these diseases.
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