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1 "Methionine synthase"
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Original Article
Interactions between vitamin B2, the MTRR rs1801394 and MTR rs1805087 genetic polymorphisms, and colorectal cancer risk in a Korean population
Madhawa Gunathilake, Minji Kim, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Epidemiol Health. 2024;46:e2024037.   Published online March 11, 2024
DOI: https://doi.org/10.4178/epih.e2024037
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AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
We explored whether the association between vitamin B2 and colorectal cancer (CRC) risk could be modified by the MTRR rs1801394 and MTR rs1805087 genetic polymorphisms and examined whether the interaction effects are sex-specific.
METHODS
We performed a case-control study involving 1,420 CRC patients and 2,840 controls from the Korea National Cancer Center. Dietary vitamin B2 intake was assessed using a semiquantitative food frequency questionnaire, and the association with CRC was evaluated. Genotyping was performed using an Illumina MEGA-Expanded Array. For gene-nutrient interaction analysis, pre-matched (1,081 patients and 2,025 controls) and matched (1,081 patients and 1,081 controls) subsets were included. Unconditional and conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS
A higher intake of vitamin B2 was associated with a significantly lower CRC risk (OR, 0.65; 95% CI, 0.51 to 0.82; p<0.001). Carriers of at least 1 minor allele of MTRR rs1801394 showed a significantly higher CRC risk (OR, 1.43; 95% CI, 1.12 to 1.83). Males homozygous for the major allele (A) of MTRR rs1801394 and who had a higher intake of vitamin B2 had a significantly lower CRC risk (OR, 0.31; 95% CI, 0.18 to 0.54; p-interaction=0.02). In MTR rs1805087, males homozygous for the major allele (A) and who had a higher vitamin B2 intake had a significantly lower CRC risk (OR, 0.38; 95% CI, 0.25 to 0.60; p-interaction<0.001).
CONCLUSIONS
The MTRR rs1801394 and MTR rs1805087 genetic polymorphisms may modify the association between vitamin B2 and CRC risk, particularly in males. However, further studies are warranted to confirm these interaction results.
Summary
Korean summary
본 연구는 환자-대조군 연구를 통해 비타민 B2 섭취와 대장암 발생의 관련성을 조사하고, 대장암 발생에 있어 methionine synthase (MTRR) rs1801394 및 methionine synthase reductase (MTR) rs1805087의 유전적 다형성과 식이 요인간에 상호작용을 알아보고자 한다. 비타민 B2 의 섭취는 대장암 발생의 위험도를 낮추는 것으로 나타났으며 특히, 남성의 경우 대장암 발생의 위험도가 MTRR rs1801394 및 MTR rs1805087의 유전자형과 식이 섭취에 따른 상호 관련성에 의해 영향을 받는 것으로 나타났다.
Key Message
We conducted a case-control study to observe the association between vitamin B2 intake and the risk of colorectal cancer (CRC), and to determine whether this association could be modified by the methionine synthase (MTRR) rs1801394 and methionine synthase reductase (MTR) rs1805087 genetic polymorphisms. Higher intake of vitamin B2 is a protective factor in lowering CRC risk, and rs1801394 of MTRR and rs1805087 of MTR may particularly modify this association in males.

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