The hygiene hypothesis (HH) proposed by Strachan in 1989 was expanded to explain the inverse association between the occurrence of allergy disorders and the risk of infectious diseases and parasite infestation. The microflora hypothesis (MH) suggests that gut microbial dysbiosis in early life might trigger hypersensitivity disorders. The sharing concept of both HH and MH is gene-environment interaction, which is also a key concept in epigenetics. The amalgamation of epidemiology and epigenetics has created a scientific discipline termed epigenetic epidemiology. To accomplish an era of gene-environment-wide interaction studies, it is necessary to launch a national human epigenome project.
Summary
Korean summary
1989년 제시된 위생가설 (Hygiene hypothesis)은 최근 체내미생물가설 (Microflora hypothesis) 대치되어 알레르기 질환의 발생기전을 해석하고 있다. 두 가설 모두 유전-환경 상호작용 gene-environment interaction) 을 강조하고 있다는 점에서 향후 후성유전역학 연구에 대한 활성화가 필요하다.
Citations
Citations to this article as recorded by
Multicenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis Zhifeng Huang, Aoli Li, Huiqing Zhu, Junxiu Pan, Jun Xiao, Jiang Wu, Yumin Han, Lili Zhong, Xuhui Sun, Lei Wang, Liang Hu, Cuihua Wang, Xingkai Ma, Zaixia Qiao, Min Zhang, Ling Yuan, Xin Liu, Jun Tang, Yue Li, Hong Yu, Zhaobing Zheng, Baoqing Sun Scientific Reports.2024;[Epub] CrossRef
A Higher Incidence of Isolated Biliary Atresia in Rural Areas Mark Nomden, Daan B.E. van Wessel, Solomon Ioannou, Henkjan J. Verkade, Ruben H. de Kleine, Behrooz Z. Alizadeh, Janneke L.M. Bruggink, Jan B.F. Hulscher Journal of Pediatric Gastroenterology and Nutrition.2021; 72(2): 202. CrossRef
Eradication of Helicobacter pylori and Gastric Cancer: A Controversial Relationship Mariagrazia Piscione, Mariangela Mazzone, Maria Carmela Di Marcantonio, Raffaella Muraro, Gabriella Mincione Frontiers in Microbiology.2021;[Epub] CrossRef
Pathogenesis of Children’s Allergic Diseases: Refocusing the Role of the Gut Microbiota Tingting Hu, Yinmiao Dong, Chenghao Yang, Mingyi Zhao, Qingnan He Frontiers in Physiology.2021;[Epub] CrossRef
Pilot study of the SCFA Headspace Analysis of Streptococcus mutans Metabolites in Media with and without Polyols Goudarzi S Habibi, B Kabat, M Cannon, M Gashkoff, R Zurek Edelweiss Journal of Biomedical Research and Review.2020; : 24. CrossRef
Blockade of enhancer of zeste homolog 2 alleviates renal injury associated with hyperuricemia Yingfeng Shi, Liuqing Xu, Min Tao, Lu Fang, Jiasun Lu, Hongwei Gu, Shuchen Ma, Tao Lin, Yi Wang, Wenfang Bao, Andong Qiu, Shougang Zhuang, Na Liu American Journal of Physiology-Renal Physiology.2019; 316(3): F488. CrossRef
Researches of Epigenetic Epidemiology for Infections and Radiation as Carcinogen Jong-Myon Bae Journal of Preventive Medicine and Public Health.2018; 51(4): 169. CrossRef
Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers Jong-Myon Bae Journal of Preventive Medicine and Public Health.2018; 51(5): 263. CrossRef