-
Effect of chemotherapy and radiotherapy on cognitive impairment in colorectal cancer: evidence from Korean National Health Insurance Database Cohort
-
Kwanghyun Kim, Chang Woo Kim, Aesun Shin, Hyunseok Kang, Sun Jae Jung
-
Epidemiol Health. 2021;43:e2021093. Published online November 2, 2021
-
DOI: https://doi.org/10.4178/epih.e2021093
-
-
14,385
View
-
206
Download
-
7
Web of Science
-
8
Crossref
-
 Abstract
Summary
 PDF Supplementary Material
-
Abstract
OBJECTIVES
We investigated the risk of chemotherapy-related and radiotherapy-related cognitive impairment in colorectal cancer patients.
METHODS Medical use data of colorectal cancer patients were obtained from the Korean National Health Insurance Database from 2004 to 2018. We randomly selected 40% of all colorectal cancer patients (n=148,848). Cognitive impairment was defined as having 1 or more International Classification of Diseases, 10th revision diagnostic codes for dementia or mild cognitive impairment. Patients aged 18 years or younger, patients diagnosed with cognitive impairment before colorectal cancer diagnosis (n=8,225), and patients who did not receive primary resection (n=45,320) were excluded. The effects of individual chemotherapy regimens on cognitive impairment were estimated. We additionally estimated the effect of radiotherapy in rectal cancer patients. Time-dependent competing risk Cox regression was conducted to estimate the overall and age-specific hazard ratios (HR) separately for colon and rectal cancer. Landmark analyses with different lag times were conducted as sensitivity analyses.
RESULTS Chemotherapy did not increase the risk of cognitive impairment in colorectal cancer patients (colon cancer: HR, 0.92; 95% confidence interval [CI], 0.83 to 1.03; rectal cancer: HR, 0.88; 95% CI, 0.75 to 1.04), while radiotherapy was negatively associated with cognitive impairment in rectal cancer patients (HR, 0.01; 95% CI, 0.84 to 0.99). Varying directions of the associations between regimens and cognitive impairment were detected. The adverse effect of certain chemotherapy regimens on cognition was more prominent in older adults.
CONCLUSIONS Chemotherapy and radiotherapy did not increase the risk of cognitive impairment. Older patients with low cognitive reserve could be affected by the adverse cognitive effects of chemotherapy.
-
Summary
Korean summary
- 대장암 환자를 대상으로 한 항암화학요법 및 방사선요법은 인지기능저하의 위험을 높이지 않았다
- 일부 항암화학요법의 경우 고령의 대장암 환자에서 인지기능저하의 위험을 증가시킬 수 있다
Key Message
Results from nationwide cohort of Korea showed that chemotherapy and radiotherapy did not increase the risk of cognitive impairment in colorectal cancer patients.
-
Citations
Citations to this article as recorded by  - Epigenetic Regulation of Nuclear Factor Erythroid-2-Related Factor 2 in Colorectal Cancer Cells Resistant to Ionizing Radiation
Kyoung Ah Kang, Jinny Park, Mei Jing Piao, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Herath Mudiyanselage Maheshika Madhuwanthi Senavirathna, Jung-Hwan Kim, Suk Ju Cho, Jin Won Hyun
Biomolecules & Therapeutics.2025; 33(1): 182. CrossRef - Research Progress: Exploring the Long-term Survival Status of Colorectal Cancer Survivors
Zhaobei Cai, Qianqian Chen, Enqiang Linghu
Clinical Cancer Investigation Journal.2024; 13(2): 34. CrossRef - Real-World Data-Derived Pharmacovigilance on Drug-Induced Cognitive Impairment Utilizing a Nationwide Spontaneous Adverse Reporting System
Yongjun Sunwoo, Sae Hyun Eom, Ji Seong Yun, Yujin Kim, Jeongmin Lee, Soo Hyeon Lee, Sooyoung Shin, Yeo Jin Choi
Medicina.2024; 60(7): 1028. CrossRef - Resting-State Brain Function Alteration in Colorectal Cancer Patients
Yanan Xu, Zihan Ma, Jieyu Chen, Huiyan Zhang, Guo Shen, Gang Huang, Wenwen Zhang, Lianping Zhao
Journal of Integrative Neuroscience.2024;[Epub] CrossRef - Predictors of cognitive impairment in patients undergoing ileostomy for colorectal cancer: a retrospective analysis
Jing Xu, Yuelan Yang, Die Hu
PeerJ.2023; 11: e15405. CrossRef - Soluble HSPG and HS relaying neuroinflammation contribute to behavioral comorbidities associated with cancer located outside the central nervous system
Yue-peng Liu, Yan-jun Yang
Medical Hypotheses.2023; 177: 111113. CrossRef - Chemotherapy-induced functional brain abnormality in colorectal cancer patients: a resting‐state functional magnetic resonance imaging study
Siwen Liu, Yesong Guo, Jie Ni, Na Yin, Chenchen Li, Xuan Pan, Rong Ma, Jianzhong Wu, Shengwei Li, Xiaoyou Li
Frontiers in Oncology.2022;[Epub] CrossRef - Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants
He-Ying Hu, Ya-Ru Zhang, Qiaolifan Aerqin, Ya-Nan Ou, Zuo-Teng Wang, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu
Translational Psychiatry.2022;[Epub] CrossRef
-
Androgen deprivation therapy is associated with decreased second primary lung cancer risk in the United States veterans with prostate cancer
-
Kyungsuk Jung, Jong Chul Park, Hyunseok Kang, Johann Christoph Brandes
-
Epidemiol Health. 2018;40:e2018040. Published online August 11, 2018
-
DOI: https://doi.org/10.4178/epih.e2018040
-
-
16,552
View
-
209
Download
-
7
Web of Science
-
6
Crossref
-
Abstract
Summary
PDFSupplementary Material
-
Abstract
OBJECTIVES
We investigated whether androgen deprivation therapy (ADT) in prostate cancer patients was associated with a decreased risk for second primary lung cancer in US veterans.
METHODS Prostate cancer diagnoses in the US Veterans Affairs Cancer Registry between 1999 and 2008 were identified. Use of hormonal therapy and diagnoses of second primary lung cancer were determined from the registry. Synchronous prostate and lung cancers, defined as 2 diagnoses made within 1 year, were excluded from the analysis. Cancer-free survival was estimated using the Kaplan-Meier method and hazard ratios were estimated using Cox proportional hazard models.
RESULTS Among the 63,141 identified patients with prostate cancer, 18,707 subjects were eligible for the study. Hormonal therapy was used in 38% of patients and the median follow-up period was 28 months. ADT use was associated with longer lung cancer-free survival in prostate cancer patients (log-rank p=0.01). After adjusting for age, race, smoking and prostate cancer stage, ADT use was associated with decreased lung cancer risk by 15, 21, and 24% after 1, 2, and 3 years, respectively.
CONCLUSIONS ADT in prostate cancer patients may be associated with decreased second primary lung cancer risk among US veterans.
-
Summary
Korean summary
비소세포성 폐암이 호르몬 수용체에 의해 영향을 받을 수 있다는 기존의 연구 결과를 바탕으로, 이 연구는 미국 재향 군인 병원 암등록 자료를 분석하여 전립선암 환자 중, 안드로겐 박탈 요법으로 치료를 받은 경우와 그렇지 않은 경우의 비소세포성 폐암 발생율을 비교분석하였다. 분석 결과, 전립선암을 진단받은 미국 재향군인들 중 안드로겐 박탈 요법으로 치료를 받은 환자들이 그렇지 않은 환자들에 비해 비소세포성 폐암 발생율이 통계적으로 유의미하게 감소하는 것이 관찰되었다.
-
Citations
Citations to this article as recorded by - Correlation between second and first primary cancer: systematic review and meta-analysis of 9 million cancer patients
Xinyu Wang, Meiyuan Zeng, Xueming Ju, Anqi Lin, Chaozheng Zhou, Junyi Shen, Zaoqu Liu, Bufu Tang, Quan Cheng, Youyu Wang, Jian Zhang, Peng Luo
British Journal of Surgery.2024;[Epub] CrossRef - New Perspectives on Sex Steroid Hormones Signaling in Cancer-Associated Fibroblasts of Non-Small Cell Lung Cancer
Chihiro Inoue, Yasuhiro Miki, Takashi Suzuki
Cancers.2023; 15(14): 3620. CrossRef - Role of sex and sex hormones in PD-L1 expression in NSCLC: clinical and therapeutic implications
Vianey Rodriguez-Lara, Giovanny Soca-Chafre, Maria Rosa Avila-Costa, Juan Jose Juarez-Vignon Whaley, Jeronimo Rafael Rodriguez-Cid, José Luis Ordoñez-Librado, Emma Rodriguez-Maldonado, Nallely A. Heredia-Jara
Frontiers in Oncology.2023;[Epub] CrossRef - Endogenous sex hormones, aromatase activity and lung cancer risk in postmenopausal never‐smoking women
Yingya Zhao, Yu‐Tang Gao, Xianglan Zhang, Alan L. Rockwood, Mark M. Kushnir, Qiuyin Cai, Jie Wu, Jiajun Shi, Qing Lan, Nathaniel Rothman, Yu Shyr, Xiao‐Ou Shu, Wei Zheng, Gong Yang
International Journal of Cancer.2022; 151(5): 699. CrossRef - Racial and ethnic differences in risk of second primary cancers among prostate cancer survivors
Diana R. Withrow, Sara J. Schonfeld, Rochelle E. Curtis, Lindsay M. Morton, Michael B. Cook, Eboneé N. Butler, Amy Berrington de González
Cancer Causes & Control.2020; 31(11): 1011. CrossRef - Sex steroid metabolism and actions in non-small cell lung carcinoma
Teeranut Asavasupreechar, Monica S.M. Chan, Ryoko Saito, Yasuhiro Miki, Viroj Boonyaratanakornkit, Hironobu Sasano
The Journal of Steroid Biochemistry and Molecular Biology.2019; 193: 105440. CrossRef
-
Green Tea Consumption and Stomach Cancer Risk: A Meta-Analysis
-
Hyunseok Kang, Sun Young Rha, Kyung Won Oh, Chung Mo Nam
-
Epidemiol Health. 2010;32:e2010001. Published online April 26, 2010
-
DOI: https://doi.org/10.4178/epih/e2010001
-
-
23,253
View
-
131
Download
-
30
Crossref
-
Abstract
PDF
-
Abstract
<sec><title>OBJECTIVES</title><p>Green tea has been suggested to have a chemopreventive effect against various cancers including stomach cancer. The aim of this study is to elucidate the relationship between green tea consumption and stomach cancer risk by meta-analysis.</p></sec><sec><title>METHODS</title><p>Eighteen observational studies were identified using MEDLINE, THE COCHRANE LIBRARY, RISS, and a manual search. Summary relative risks/odds ratios (RR/ORs) for the highest versus non/lowest green tea consumption levels were calculated on the basis of fixed and random effect models. Subgroup analyses were used to examine heterogeneity across the studies.</p></sec><sec><title>RESULTS</title><p>The combined results indicate a reduced risk of stomach cancer with intake of green tea (RR/OR=0.86, 95% CI=0.74-1.00). Subgroup analysis with six studies that reported differences between the highest and lowest consumption levels equal to or greater than five cups/day revealed a statistically significant protective effect (RR/OR=0.68, 95% CI=0.53-0.87).</p></sec><sec><title>CONCLUSION</title><p>Green tea appears to play a protective role against the development of stomach cancer. The results also suggest that a higher level of green tea consumption might be needed for a clear preventive effect to appear. This conclusion, however, should be interpreted with caution because various biases can affect the results of a meta-analysis.</p></sec>
-
Summary
-
Citations
Citations to this article as recorded by - Association between green tea intake and digestive system cancer risk in European and East Asian populations: a Mendelian randomization study
Duorui Nie, Xiaoyu He, Hao Zheng, Deyu Deng, Fanghui He, Ruyi Li, Xiaoting Ni, Shunxiang Li, Fei Xu
European Journal of Nutrition.2024; 63(4): 1103. CrossRef - Sex differences in the benefit of tea consumption: A critical summation of the epidemiological evidence
Changhuai He, Pin Ye, Xuecheng Zhang, Yiqing Li, Qingping Li, Ping Lü, Chuanqi Cai, Xun Cai
Food Bioscience.2024; 58: 103716. CrossRef - In situ global proteomics profiling of EGCG targets using a cell-permeable and Click-able bioorthogonal probe
Revathy Sahadevan, Anupama Binoy, Sai K. Vechalapu, Pandurangan Nanjan, Sushabhan Sadhukhan
International Journal of Biological Macromolecules.2023; 237: 123991. CrossRef - Pancreatic cancer risk: alcoholic and non-alcoholic beverages
Irina N. Grigor’eva
Terapevticheskii arkhiv.2022; 94(2): 265. CrossRef - Diet and gastric cancer risk: an umbrella review of systematic reviews and meta-analyses of prospective cohort studies
Shu-Jun Liu, Pi-Di Huang, Jia-Min Xu, Qian Li, Jian-Hui Xie, Wen-Zhen Wu, Chen-Tong Wang, Xiao-Bo Yang
Journal of Cancer Research and Clinical Oncology.2022; 148(8): 1855. CrossRef - Anticarcinogenic potentials of tea catechins
Xiao-Xiang Li, Chang Liu, Shu-Ling Dong, Can-Song Ou, Jian-Liang Lu, Jian-Hui Ye, Yue-Rong Liang, Xin-Qiang Zheng
Frontiers in Nutrition.2022;[Epub] CrossRef - Green tea and cancer and cardiometabolic diseases: a review of the current epidemiological evidence
Sarah Krull Abe, Manami Inoue
European Journal of Clinical Nutrition.2021; 75(6): 865. CrossRef - Antimetastatic Properties of Tea Polyphenols
Niladri Bag, Arundhati Bag
Nutrition and Cancer.2020; 72(3): 365. CrossRef - Nanoencapsulated Dietary Polyphenols for Cancer Prevention and Treatment: Successes and Challenges
Shams Tabrez, Nasimudeen R Jabir, Vaqar Mustafa Adhami, Mohammad Imran Khan, Mohammed Moulay, Mohammad Amjad Kamal, Hasan Mukhtar
Nanomedicine.2020; 15(11): 1147. CrossRef - In Search of Panacea—Review of Recent Studies Concerning Nature-Derived Anticancer Agents
Dawid Przystupski, Magdalena J. Niemczura, Agata Górska, Stanisław Supplitt, Krzysztof Kotowski, Piotr Wawryka, Paulina Rozborska, Kinga Woźniak, Olga Michel, Aleksander Kiełbik, Weronika Bartosik, Jolanta Saczko, Julita Kulbacka
Nutrients.2019; 11(6): 1426. CrossRef - The Cytoprotective Role of Antioxidants in Mammalian Cells Under Rapidly Varying UV Conditions During Stratospheric Balloon Campaign
Dawid Przystupski, Agata Górska, Paulina Rozborska, Weronika Bartosik, Olga Michel, Joanna Rossowska, Anna Szewczyk, Małgorzata Drąg-Zalesińska, Paulina Kasperkiewicz, Jędrzej Górski, Julita Kulbacka
Frontiers in Pharmacology.2019;[Epub] CrossRef - Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer
Shreena J. Desai, Ben Prickril, Avraham Rasooly
Nutrition and Cancer.2018; 70(3): 350. CrossRef - Green Tea Consumption and the Risk of Liver Cancer: A Meta-Analysis
Chen-Xu Ni, Hong Gong, Ying Liu, Yang Qi, Chun-Lei Jiang, Jun-Ping Zhang
Nutrition and Cancer.2017; 69(2): 211. CrossRef - An inverse association between tea consumption and colorectal cancer risk
Yuetong Chen, Yuan Wu, Mulong Du, Haiyan Chu, Lingjun Zhu, Na Tong, Zhengdong Zhang, Meilin Wang, Dongying Gu, Jinfei Chen
Oncotarget.2017; 8(23): 37367. CrossRef - Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy
Andreia Granja, Marina Pinheiro, Salette Reis
Nutrients.2016; 8(5): 307. CrossRef - Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: Results from the EPIC cohort study
Harinakshi Sanikini, Vincent K. Dik, Peter D. Siersema, Nirmala Bhoo‐Pathy, Cuno S.P.M. Uiterwaal, Petra H.M. Peeters, Carlos A. González, Raul Zamora‐Ros, Kim Overvad, Anne Tjønneland, Nina Roswall, Marie‐Christine Boutron‐Ruault, Guy Fagherazzi, Antoine
International Journal of Cancer.2015;[Epub] CrossRef - Methylenetetrahydrofolate reductase (MTHFR) polymorphism susceptibility to schizophrenia and bipolar disorder: an updated meta-analysis
Cai-Yun Hu, Zhen-Zhong Qian, Feng-Feng Gong, Shan-Shan Lu, Fang Feng, Yi-Le Wu, Hui-Yun Yang, Ye-Huan Sun
Journal of Neural Transmission.2014;[Epub] CrossRef - Association of Risk of Gastric Cancer and Consumption of Tobacco, Alcohol and Tea in the Chinese Population
Gui-Xian Tong, Han Liang, Jing Chai, Jing Cheng, Rui Feng, Peng-Lai Chen, Qing-Qing Geng, Xing-Rong Shen, De-Bin Wang
Asian Pacific Journal of Cancer Prevention.2014; 15(20): 8765. CrossRef - Green Tea Consumption and Risk of Pancreatic Cancer: A Meta-analysis
Jin-Long Zeng, Zhi-Hua Li, Zhi-Chao Wang, Hai-Liang Zhang
Nutrients.2014; 6(11): 4640. CrossRef - Tea consumption and the risk of five major cancers: a dose–response meta-analysis of prospective studies
Feifei Yu, Zhichao Jin, Hong Jiang, Chun Xiang, Jianyuan Tang, Tuo Li, Jia He
BMC Cancer.2014;[Epub] CrossRef - Evidence-based assessment of proton-pump inhibitors inHelicobacter pylorieradication: A systematic review
Vinayak Nagaraja
World Journal of Gastroenterology.2014; 20(40): 14527. CrossRef - Coffee and beverages are the major contributors to polyphenol consumption from food and beverages in Japanese middle-aged women
Yoichi Fukushima, Takeshi Tashiro, Akiko Kumagai, Hiroyuki Ohyanagi, Takumi Horiuchi, Kazuhiro Takizawa, Norie Sugihara, Yoshimi Kishimoto, Chie Taguchi, Mariko Tani, Kazuo Kondo
Journal of Nutritional Science.2014;[Epub] CrossRef - Tea consumption and prostate cancer: an updated meta-analysis
Yi-wei Lin, Zheng-hui Hu, Xiao Wang, Qi-qi Mao, Jie Qin, Xiang-yi Zheng, Li-ping Xie
World Journal of Surgical Oncology.2014;[Epub] CrossRef - Health-promoting effects of green tea
Yasuo SUZUKI, Noriyuki MIYOSHI, Mamoru ISEMURA
Proceedings of the Japan Academy, Series B.2012; 88(3): 88. CrossRef - Flavonoids and Cancer Prevention: A Review of the Evidence
Donato F. Romagnolo, Ornella I. Selmin
Journal of Nutrition in Gerontology and Geriatrics.2012; 31(3): 206. CrossRef - Overview of Methodological Quality of Systematic Reviews about Gastric Cancer Risk and Protective Factors
Lun Li, Xiang-Ji Ying, Tian-Tian Sun, Kang Yi, Hong-Liang Tian, Rao Sun, Jin-Hui Tian, Ke-Hu Yang
Asian Pacific Journal of Cancer Prevention.2012; 13(5): 2069. CrossRef - Growth inhibition of Walker carcinosarcoma 256 with alcoholic extract of green tea leaves (Camellia sinensis)
Mauriclécio Franco Ponte, Thiago Sousa e Silva Targino, Matheus Alves de Lima Mota, José Saul Peixoto Landim, Thyciana Rodrigues Ribeiro, Fabiana Pereira Soares, Márcio Roberto Pinho Pereira, Sônia Leite da Silva, Silvia Fernandes Ribeiro da Silva
Acta Cirurgica Brasileira.2012; 27(9): 634. CrossRef - Prospective cohort study of tea consumption and risk of digestive system cancers: results from the Shanghai Women's Health Study
Sarah Nechuta, Xiao-Ou Shu, Hong-Lan Li, Gong Yang, Bu-Tian Ji, Yong-Bing Xiang, Hui Cai, Wong-Ho Chow, Yu-Tang Gao, Wei Zheng
The American Journal of Clinical Nutrition.2012; 96(5): 1056. CrossRef - Relationships between black tea consumption and key health indicators in the world: an ecological study
Ariel Beresniak, Gerard Duru, Genevieve Berger, Dominique Bremond-Gignac
BMJ Open.2012; 2(6): e000648. CrossRef - What Should be Taken into Consideration for a Meta-Analysis of Green Tea Consumption and Stomach Cancer Risk?
Jeongseon Kim
Epidemiology and Health.2010; 32: e2010012. CrossRef
|
KSE
