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- Cohort profile: a nationwide retrospective cohort of mortality in people living with HIV in the Republic of Korea, 1985-2020
- Taeyoung Kim, Yoonhee Jung, Koun Kim, Jung Wan Park, Jeonghee Yu, Sung-il Cho
- Epidemiol Health. 2025;e2025002. Published online January 2, 2025
- DOI: https://doi.org/10.4178/epih.e2025002 [Accepted]
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AbstractThe increasing number of people living with HIV in Korea has prompted interest in using the national surveillance system as a database for studying their health. To investigate the relationships between sociodemographic and epidemiological characteristics and mortality rates, a nationwide retrospective cohort was formed by integrating surveillance data with the Cause of Death Statistics from Statistics Korea. This integration included incidence reports, epidemiological investigations, and death reports from the surveillance data, enriched with detailed mortality information from the Cause of Death data. The cohort comprised 17,199 adult Korean individuals diagnosed with HIV infection from 1985 to 2020. By the end of 2020, 2,721 of these individuals were confirmed deceased. The sex ratio of the study participants was 14.3:1 (male to female), with 78.2% being under 50 years old at the time of diagnosis. Sexual contact was identified as the primary transmission route, accounting for 75.7% of cases. HIV disease emerged as the predominant cause of death, representing two-thirds (1,817 of 2,721) of the fatalities, followed by injuries and trauma, malignancies, and cardiovascular diseases. Recommendations for further cohort studies may be submitted to the Korea Disease Control and Prevention Agency.
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SummaryOriginal article
- Prospective association between handgrip strength in childhood and the metabolic syndrome score and insulin resistance indices in adolescence: an analysis based on the Ewha Birth and Growth Study
- Seunghee Jun, Hyunjin Park, Hyelim Lee, Hye Ah Lee, Young Sun Hong, Hyesook Park
- Epidemiol Health. 2025;e2025001. Published online January 2, 2025
- DOI: https://doi.org/10.4178/epih.e2025001 [Accepted]
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Abstract
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AbstractOBJECTIVES
Low handgrip strength in children and adolescents might be associated with the risk of metabolic syndrome (MetS) and insulin resistance. This study prospectively evaluated the association between handgrip strength (HGS) in childhood and MetS in adolescence.METHODSBased on data from the Ewha Birth and Growth Study, this study analyzed handgrip strength at ages 7 to 9 and metabolic indices at ages 13 to 15. In total, 219 participants were analyzed. The risk of MetS was evaluated using the continuous MetS score (cMetS), and insulin resistance was assessed using fasting blood insulin and homeostasis model assessment of insulin resistance (HOMA-IR). Relative handgrip strength in childhood was determined by dividing handgrip strength by body weight and categorized as sex-specific quartiles.RESULTSThis study found an inverse association between relative handgrip strength levels in childhood and MetS and insulin resistance in adolescence. For each 1-group increase in relative handgrip strength quartiles, cMetS (Std. β=-0.64, p<0.01), HOMA-IR (Std. β=-0.21, p<0.01), and fasting blood insulin (Std. β=-0.21, p<0.01) all decreased on average. These associations remained significant even after adjusting for confounding factors.CONCLUSIONSOur study showed a prospective association between handgrip strength in childhood and the risk of MetS and insulin resistance in adolescence. It provides significant epidemiological evidence, emphasizing the importance of efforts to increase muscle strength from a young age to mitigate the risk of MetS and insulin resistance in adolescence. -
SummaryKorean summary
본 연구는 소아기 악력 수준이 청소년기의 대사증후군 및 인슐린 저항성과 연관이 있음을 발견했음. 이러한 결과는 소아기 근력 향상이 향후 대사 위험을 완화하는데 중요함을 강조함.Key Message
This study found that higher childhood relative handgrip strength was inversely associated with metabolic syndrome and insulin resistance in adolescence. The findings emphasize the importance of enhancing muscle strength early in life to mitigate metabolic risks.
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