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Korean J Parasitol. 2009 Sep;47(3):197-204.
Published online 2009 August 28.  doi: 10.3347/kjp.2009.47.3.197.
Copyright © 2009 by The Korean Society for Parasitology
Trypanosome Glycosylphosphatidylinositol Biosynthesis
Yeonchul Hong,1 and Taroh Kinoshita2
1Department of Parasitology, Kyungpook National University School of Medicine, Daegu 700-422, Korea.
2Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

Corresponding author (Email: ychong@knu.ac.kr )
Received May 09, 2009; Revised July 30, 2009; Accepted July 30, 2009.

Abstract

Trypanosoma brucei, a protozoan parasite, causes sleeping sickness in humans and Nagana disease in domestic animals in central Africa. The trypanosome surface is extensively covered by glycosylphosphatidylinositol (GPI)-anchored proteins known as variant surface glycoproteins and procyclins. GPI anchoring is suggested to be important for trypanosome survival and establishment of infection. Trypanosomes are not only pathogenically important, but also constitute a useful model for elucidating the GPI biosynthesis pathway. This review focuses on the trypanosome GPI biosynthesis pathway. Studies on GPI that will be described indicate the potential for the design of drugs that specifically inhibit trypanosome GPI biosynthesis.

Keywords: Trypanosoma brucei, trypanosome, glycosylphosphatidylinositol, glycoprotein, biosynthesis.
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